A PEDIGREE OF HUNTINGTON'S CHOREA

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Sydenham's Chorea

Sydenham’s chorea is a delayed complication of group Aßhaemolytic streptococcal infections and forms one of the majorcriteria of acute rheumatic fever.It is characterised bychorea, muscular weakness, and a number of neuropsychiatricsymptoms. It is considered to be an autoantibody mediated disorderwith the evidence suggesting that patients with Sydenham’schorea produce antibodies that cross reac...

A Case of Rheumatic Chorea

Rheumatic chorea: a video demonstration.

DISCUSSION This patient had no family history of movement disorder. He never had seizures or intellectual impairment. His blood examination showed normal complete blood count and erythrocyte sedimentation rate along with a normal antistreptolysin O titre. Movement disorder in this 10-year-old boy (video 1) is characterised by rapid uncoordinated, jerking movements mainly in face, hands and feet...

Huntington's chorea.

The pharmacological treatment of Huntington's chorea has been based on the use of neuroleptic drugs, on the hypothesis that there is a functional dopaminergic hyperactivity in this illness (Agid, 1975). More recently, after the observation of reduced cholinergic and GABAminergic activity at the striatal level in brains of choreic subjects (McGeer et al., 1973; Stahl and Swanson, 1974; Bird and ...